Endocrine Abstracts

Osteocalcin (OC) is the main non-collagenous protein of the bone and it has a regulatory role in mineralization. Extra-skeletal roles have been recently hypothesized for OC (e.g., modulation of glucose-induced insulin secretion by interacting with GPRC6A in β-cells). However, OC-mediated GPRC6A activation has been demonstrated only in rodents and heterologous systems. In this study we aimed at evaluating the dose-dependent response to OC and the eventual activation of the...

Introduction: GPRC6A is a widely expressed seven-transmembrane G-protein coupled receptor mediating L-α-amino acids signaling (mainly, arginine, lysine, and ornithine), which has been proposed as receptor for osteocalcin. By interacting with GPRC6A, in β-cells, osteocalcin is thought to modulate the glucose-induced insulin secretion. However, GPRC6A functions have been studied only in rodents or in rodents-derived cells.Aim of th...

Introduction: Bone and energy metabolisms are deeply related determining a two-way street aimed in regulating the energy utilization [1]. Mountain ultra-marathons are peculiar aerobic performances hardly proving whole body homeostasis [2]. In this study we aimed at investigating and characterizing the metabolic profile (hormones involved in energy metabolism), the metabolic inflammation profile (adipokines), the bone metabolism (bone turnover markers), and their integration (m...

Introduction: Although underlying mechanisms are largely unknown, bone metabolism is regulated by specific microRNAs and changes in their expression are associated with metabolic bone disorders. Exercise is a determinant of bone metabolism; however, different training protocols differently affect bone. Little is known about the effects of exercise on bone-specific miRNA expression.We studied the effect of a 8-week high-intensity training protocol on circ...

IntroductionIrisin is a molecule secreted from skeletal muscle and contributes to maintenance of metabolic homeostasis leading to increased energy expenditure and reducing the risk of obesity and diabetes. Literature data suggest that patients with Cushing disease have lower irisin values than controls and remission of hypercortisolism increases these values. Moreover, other plasma inflammation markers implicated in the pathogenesis of atherosclerosis, i...

Parathyroid glands regulate bone metabolism through PTH, while bone modulates parathyroid function through calcium and FGF23. Bone releases the matrix protein osteocalcin (OC), whose hormone function is increasingly evident. We tested the hypothesis that OC may modulate parathyroid function. The 6 hours-stimulation of human parathyroid cells derived from adenomas (PAds) (n = 5) with γ-carboxylated OC (GlaOC; 40–60 ng/ml) increased the expression levels ...

Parathyroid glands regulate bone metabolism through PTH, while bone modulates parathyroid function through calcium and FGF23. We tested the hypothesis that the matrix protein osteocalcin (OC), secreted by osteoblasts, may modulate parathyroid function. In human parathyroid cells derived from adenomas (PAds), incubation with g-carboxylated OC (GlaOC) or undercarboxylated OC (GluOC) modulated the intracellular signaling pathways: both GlaOC and GluOC inhibited the basal phosphor...